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Therefore, inhibition of cystine uptake can rapidly induce breast cancer cell death, particularly affecting TNBC cells, which inhibits tumor progression and growth (28)

Therefore, we next performed flow cytometric analyses of tumor-infiltrating CD45 + leukocytes, tumor-draining lymph nodes (tdLNs) and splenocytes from MCA205 tumor-bearing mice treated by systemic PD-1 blockade alone or together with L-histidine (Fig

Neither route has a completed human safety profile

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